July 3, 2019 – Tumors and Blood

June 27, 2019

Play

Anchor lead: Can understanding blood flow in a tumor lead to better treatment? Elizabeth Tracey reports

What’s the best approach to treating a tumor? A new modeling method for assessing blood supply, critical to a tumor’s growth and survival, may help. That’s according to Arvind Pathek, an imaging expert at Johns Hopkins, and colleagues, who’ve developed a Google maps-like solution to the problem.

Pathek: The distribution of the blood in a tumor depends upon how much blood is delivered to the tumor and if the tumor is not what we call well-perfused, so it does not have a very good blood supply, then it doesn’t matter how much of the drug you give, not enough is going to be delivered. So it’s a very powerful tool for modeling drugs of different sizes, looking at blood distribution of tumor types, so we’ve actually created a framework where we use imaging data in conjunction with mathematical tools and models to create very realistic simulations of what these drugs are going to do in cancer.  :30

Pathek notes that tumor blood vessels are quite different from normal ones in both structure and function, and modeling helps take that into account. At Johns Hopkins, I’m Elizabeth Tracey.

Previous post:

Next post: