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Vaccination against the human papilloma virus, or HPV, all but eliminates cervical cancer in those who receive the vaccine early and complete the vaccine series, a study from the UK finds. William Nelson, director of the Kimmel Cancer Center at Johns Hopkins, describes the findings.

Nelson: The overall story is a really good one. They estimated that by June 30 of 2019 there had been 448 fewer cervical cancers that would have otherwise occurred, and 17,000 or more fewer cases of the cancer precursor condition among the girls who had been vaccinated. All told it had almost eliminated cervical cancer in women born since September 1, 1995, in other words the youngest group that got vaccinated.  :30

Nelson says current vaccines are effective against several subtypes of the HPV virus so protection should be even more comprehensive, and notes that boys too should receive the vaccine. At Johns Hopkins, I’m Elizabeth Tracey.

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Medicare developed a program to rein in the costs of cancer treatment, but the results were disappointing, a new study reveals, with this comprehensive approach reducing costs by about 1%. William Nelson, director of the Kimmel Cancer Center at Johns Hopkins, says newer therapies may eventually result in lower costs for cancer care.

Nelson: Thirty percent of the costs of this were for the drugs themselves. I wonder whether the progress towards drugs that are less toxic, hair doesn’t fall out, white blood cell counts don’t drop. Many of them are taken orally, so the expense of delivery is not going to be as great. If we get more people treated earlier in the course of the disease with less toxic therapies, that the other main driver of cost, which is the need for people to show up in emergency rooms, be hospitalized for treatment complications, won’t slowly but surely be less and less. :31

As cancer cases rise worldwide, developing approaches to contain costs is critical. At Johns Hopkins, I’m Elizabeth Tracey.

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The Covid-19 spike protein allows it to attach to cells and infect them, and it’s been a primary target for vaccines and antibodies. Now a new monoclonal antibody directed against a region of this protein that really doesn’t change very much has been developed, and Brian Garibaldi, a critical care medicine expert at Johns Hopkins, says that’s great, but there are still barriers to treatment.

Garibaldi: While its easier to administer something subq or intramuscular, you still have to watch people for potential infusion or injection site reactions and the biggest challenge right now is space and staff.  We’ve seen critical shortages at all levels of healthcare. Remember these are all for the most part patients who are going to have Covid. So you have to have a designated space in an already busy healthcare environment to administer that drug. I think that’s led to a lot of health systems not being able to keep up with the demand.  :28

Garibaldi says this antibody should be useful against more variants of Covid-19. At Johns Hopkins, I’m Elizabeth Tracey.

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Another monoclonal antibody against Covid-19 has been developed and appears to work in reducing severe disease and hospitalization. This one is unique, however, according to Brian Garibaldi, a critical care medicine expert at Johns Hopkins.

Garibaldi: The interesting thing about the new monoclonal antibody, sotrovimab, this monoclonal antibody was developed using antibodies from individuals who were infected with Sars-CoV1. It targets a more conserved region of the spike protein and the hope would be that this type of monoclonal antibody would be less likely to come across viruses that are resistant to its action. So far we have not seen delta being resistant to the other currently available monoclonals but you can imagine that we might encounter a variant down the road that might be.  :29

Garibaldi says monoclonal antibodies are still limited to those who come forward for treatment within a few days of infection, and must be administered in settings that allow for observation as well as protection of others from Covid-19. At Johns Hopkins, I’m Elizabeth Tracey.

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Monoclonal antibodies remain a treatment option for those in early stages of Covid infection, even in the face of new oral medications that likely will be available soon. Brian Garibaldi, a critical care medicine expert at Johns Hopkins, says the data are persuasive.

Garibaldi: High risk individuals who are household contacts of people who have documented Covid, they got randomized to getting subcutaneous administration of monoclonals versus placebo. At a month it was about 80% effective in symptomatic infection. Eight months after that initial prophylactic infusion protection still holds to about 80%. So it’s likely that people who get monoclonal antibodies these antibodies are going to circulate at pretty high concentrations for months. We currently recommend that you don’t get vaccinated until 90 days past your initial monoclonal antibody infusion.  :31

Garibaldi notes that monoclonals are not a substitute for vaccination, however, so when you are eligible to receive the vaccine you should do so. And monoclonals require supervised administration and observation afterward. At Johns Hopkins, I’m Elizabeth Tracey.

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Both Pfizer and Merck have recently revealed promising data on oral medicines for early Covid-19 infection, with both companies on the threshold of widespread use of the drugs. Brian Garibaldi, a critical care medicine expert at Johns Hopkins, says he hopes people don’t see these new medicines as a reason to forgo vaccination.

Garibaldi: I have lost the ability to predict how people are going to respond to different therapies, and the reason I say this is that there are many people who were not willing to get vaccinated but have no problem taking a monoclonal antibody. If you’re going to follow the science, millions and millions of people have gotten the different mRNA vaccines, and the Johnson and Johnson vaccine. It doesn’t make sense to choose to forgo a vaccine, take the risk of getting ill and if you get ill I’m going to take this other therapy that’s also brand new for Covid that’s been tested on less people.  :27

Garibaldi says these new oral medicines have even less of a record, so vaccination is still the best strategy to protect yourself and others. At Johns Hopkins, I’m Elizabeth Tracey.

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Pfizer has asked the FDA to approve its new oral medication for Covid-19, called Paxlovid, for people in the early stages of infection. Brian Garibaldi, a critical care medicine expert at Johns Hopkins, reviews the data.

Garibaldi: From symptom onset to receipt of drug within about three days they had about 750 or so patients enrolled. This drug reduced hospitalization by almost 90%, three people who got the drug got hospitalized compared to 27 who got placebo. There were seven deaths in the placebo group and no deaths in the group that got the Pfizer drug. And then when they extended that population to look at people who got it within five days of symptoms they had similar benefits. If this pans out, having an oral treatment that can reduce hospitalizations and death would be an unbelievable addition to what we currently do for Covid outpatients.  :34

Such a medication would be a boon for low and middle income countries, where vaccines have been difficult or impossible to obtain. At Johns Hopkins, I’m Elizabeth Tracey.