Can the erectile dysfunction drug sildenafil help stave off Alzheimer’s disease? Elizabeth Tracey reports


Examining the medical records of more than 265,000 men has revealed that those who took the erectile dysfunction drug sildenafil experienced a reduced rate of Alzheimer’s disease in comparison to those who did not. Lolita Nidadavolu, a geriatrics expert at Johns Hopkins and co-author of an editorial on the study, says if this finding is validated it could help many.

Nidadavolu: The FDA has already approved sildenafil or Viagra and other associated drugs in that class and they've been in use by the public for many years, so we have a pretty good handle on their safety profiles. And so to be able to find other populations besides men with the erectile dysfunction that can benefit from it would be a great benefit to more individuals. especially to help with cognition.    :26

Nidadavolu says repurposing drugs is a very attractive strategy since it brings new treatments quickly by avoiding many clinical trials. At Johns Hopkins, I’m Elizabeth Tracey.